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Arthritis

Lyme borreliosis and Salmonella

Lyme borreliosis

Lyme borreliosis (LB) is an infectious multisystemic disease, most often manifesting in skin, joints and neuronal regions. LB is transmitted to humans during the blood feeding of hard ticks of the genus Ixodes.
Up to 35 % of ticks are infected with borrelia. Following the discovery of the spirochete (spiral-shaped bacterium) Borrelia burgdorferi s.l. as the causative agent of LB, the disease emerged as the most prevalent arthropod-borne infection in northern temperate climate zones around the world. Three different species have been identified as most prominent: Borrelia burgdorferi sensu strictu, B. garinii and B. afzelii.

The Diagnosis

In combination with clinical manifestations, laboratory diagnosis is used as a confirmation of clinical suspicion. Depending on the stage of manifestation, the laboratory diagnosis is based on the detection of borrelia -specific IgM and IgG antibodies in the serum, plasma or CSF (cerebrospinal fluid) of patients.

The presence of specific IgM antibodies can often be detected very early after an initial infection (erythema migrans). In contrast, chronic infections are basically characterized by the presence of specific IgG antibodies.
Because of their broad antigen spectrum the IMTEC-Borrelia ELISAs possess high sensitivity – perfect as a screening tool! The antigen coating variants of both tests feature:

Highly sensitive lysate antigens of all relevant
borrelia species
Highly specific marker antigens (native OspC and
recombinant VlsE)

These aspects ensure the highest possible accuracy in the screening and monitoring of lyme disease patients at any time during disease progression.

Salmonella

Reactive arthritis (ReA) is the second most common form of arthritis and shows chronic progression in up to 40 % of cases. An early diagnosis based on a careful clinical case history and laboratory work-up is therefore essential. Especially Salmonella infections caused by pathogens with identical O-antigens (group B and D) are closely linked to ReA. High IgA-class antibody titres against these Salmonella serotypes are a highly sensitive marker for the diagnosis of ReA. As the widely used Widal agglutination test mainly detects IgM-class antibodies and therefore has a low sensitivity, it is therefore not suitable for this purpose. On this basis, IMTEC has developed a unique test system for the reliable diagnosis of reactive arthritis.
The IMTEC Anti-Salmonella ELISA utilizes lipopolysaccharides specific for S. typhimurium and S. enteritidis and thereby ensures a sensitivity superior to other test systems.

Advantages of the Anti-Salmonella ELISA:

Highly sensitive and specific detection of
persistent salmonella infections
Easy to automate
Ready to use reagents and controls
No pathogen culture required
Higher sensitivity (88.5 %) than the Widal test
(38.5 %) for the diagnosis of persistent salmonella
infections
Cut-off controls for reliable interpretation
Unique ELISA based on lipopolysaccharides
of S. typhimurium and S. enteritidis
Determination of IgA or IgG/IgA/IgM

For more information, please select from the following list:

IMTEC-Borrelia-Antibodies IgM

ELISA for the Detection of Borrelia - specific IgM Antibodies | 96 Tests

ITC40001

IMTEC-Borrelia-Antibodies IgG

ELISA for the Detection of Borrelia - specific IgG Antibodies | 96 Tests

ITC40011

IMTEC-Salmonella-Antibodies Screen (cut-off)

ELISA for the Detection of Antibodies against S. typhimurium and S. enteritidis (Ig(GAM)) | 96 Tests

ITC40040

IMTEC-Salmonella-Antibodies IgA (cut-off)

ELISA for the Detection of Antibodies against S. typhimurium and S. enteritidis (IgA) | 96 Tests

ITC40050

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