Immune Complexes
The detection of circulating immune complexes and their clinical relevance is currently for a number of diseases still the subject of controversy. Even though their detection can be helpful in a number of different autoimmune diseases, the underlying mechanisms of their relevance are not completely understood.
Systemic lupus erythematosus (SLE) can be characterized as a classical model of an immune complex disease.
The determination of immune complexes is included in laboratory routines in various areas:
- To estimate the severity of a disease
- To review the success of therapy
- The diagnosis of diseases in which a pathological CIC level has clinical implications for therapy
If the quantity of immune complexes formed exceeds the absorption capacity of the phagocytes, circulating immune complexes can be detected in serum.
The immune complexes are deposited and may be found located in vessel walls and organs (eg. glomerulonephritis), which leads to activation of the complement system. Through the initiation of an inflammatory response and the corresponding influence on clotting, the balance of the blood homeostasis is disturbed.
Elevated levels of circulating immune complexes can be found in different diagnostic areas: The immune complexes are deposited and may be found located in vessel walls and organs (eg. glomerulonephritis), which leads to activation of the complement system. Through the initiation of an inflammatory response and the corresponding influence on clotting, the balance of the blood homeostasis is disturbed.
- Rheumatic Disease Spectrum
- Chronic polyarthritis (see classification criteria for RA (ACR, 1987))
- SLE
- Sjogren's Syndrome
- MCTD
- Panarteritis nodosa
- Felty Syndrome
- Behcet's Syndrome
- Churg-Strauss Syndrome
- M. Bechterew (see HLA-B-27)
- M. Reiter
IMTEC-CIC Screen (cut-off)
ELISA for the Detection of C1q Binding Circulating Immune Complexes (Ig(GM)) | 96 Tests
ITC59030
IMTEC-CIC IgG
ELISA for the Quantitative Determination of C1q Binding Circulating Immune Complexes (IgG) | 96 Tests
ITC59031
IMTEC-C3d-CIC
ELISA for the Quantitative Determination of Circuláting C3d-binding Immune Complexes (IgG) | 96 Tests
ITC 59032
IMTEC-Complement Activity
ELISA for the Quantitative Determination of Complement Activity | 96 Tests
ITC59035
© 2012 HUMAN GmbH, Wiesbaden • All rights reserved